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Anatomie fast. Der Crashkurs by Antje Sander, Stefan Schwarz PDF

Posted On March 14, 2018 at 4:25 pm by / Comments Off on Anatomie fast. Der Crashkurs by Antje Sander, Stefan Schwarz PDF

By Antje Sander, Stefan Schwarz

ISBN-10: 3898622223

ISBN-13: 9783898622226

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Extra resources for Anatomie fast. Der Crashkurs

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A number of studies based on PGA/P4HB have confirmed the importance of dynamic cell culture conditions that reproduce physiological mechanical stress and of pulsatile flow to achieve optimally functional scaffolds [43, 45, 46, 255, 259]. A bioreactor that includes dynamic flexure as a major mode of deformation in the native heart valve cusp has been tested on PGA/P4HB and PLLA/P4HB composite scaffolds [270].

Blood contact, “soft” tissue, “hard” tissue). However, there is now a significant body of research data available confirming that P3HB is a completely resorbable polymer, with a degradation rate comparable to that of slowly degrading synthetic polyesters such as high molecular weight PLLA. Most valuable for an estimate of the in vivo resorption time of P3HB are studies conducted in sheep which demonstrated the resorption of arterial implants (blood contact) after approximately 12–24 months and pericardial implants (“soft” tissue contact) after approximately 30 months (see below).

M. in rats was characterized by a short acute inflammation period (up to 2 weeks) followed by the formation of a fibrous capsule of less than 200 µm thickness during weeks 4 to 8, which was reduced to 40–60 µm after 4–6 months. Forty eight weeks after surgery, the fibrous capsule surrounding the implants was minimal. Monoand polynuclear macrophages were still abundant at this time. The tissue response to P3HB and P3HB-3HV fibers was similar in terms of inflammatory reaction and fibrous capsule formation.

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Anatomie fast. Der Crashkurs by Antje Sander, Stefan Schwarz


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