Anatomie fast. Der Crashkurs by Antje Sander, Stefan Schwarz PDF
By Antje Sander, Stefan Schwarz
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Extra resources for Anatomie fast. Der Crashkurs
A number of studies based on PGA/P4HB have conﬁrmed the importance of dynamic cell culture conditions that reproduce physiological mechanical stress and of pulsatile ﬂow to achieve optimally functional scaffolds [43, 45, 46, 255, 259]. A bioreactor that includes dynamic ﬂexure as a major mode of deformation in the native heart valve cusp has been tested on PGA/P4HB and PLLA/P4HB composite scaffolds .
Blood contact, “soft” tissue, “hard” tissue). However, there is now a signiﬁcant body of research data available conﬁrming that P3HB is a completely resorbable polymer, with a degradation rate comparable to that of slowly degrading synthetic polyesters such as high molecular weight PLLA. Most valuable for an estimate of the in vivo resorption time of P3HB are studies conducted in sheep which demonstrated the resorption of arterial implants (blood contact) after approximately 12–24 months and pericardial implants (“soft” tissue contact) after approximately 30 months (see below).
M. in rats was characterized by a short acute inﬂammation period (up to 2 weeks) followed by the formation of a ﬁbrous capsule of less than 200 µm thickness during weeks 4 to 8, which was reduced to 40–60 µm after 4–6 months. Forty eight weeks after surgery, the ﬁbrous capsule surrounding the implants was minimal. Monoand polynuclear macrophages were still abundant at this time. The tissue response to P3HB and P3HB-3HV ﬁbers was similar in terms of inﬂammatory reaction and ﬁbrous capsule formation.
Anatomie fast. Der Crashkurs by Antje Sander, Stefan Schwarz