Immunology

Download PDF by Ricard Cervera, Gerard Espinosa, Munther Khamashta MD FRCP : Antiphospholipid Syndrome in Systemic Autoimmune Diseases

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By Ricard Cervera, Gerard Espinosa, Munther Khamashta MD FRCP PhD

ISBN-10: 0444531696

ISBN-13: 9780444531698

Antiphospholipid syndrome is an autoimmune disorder that factors irregular blood clots. it truly is now famous as a huge reason for universal stipulations, together with stroke, middle assault, miscarriage, epilepsy and reminiscence loss and as such is gaining popularity in all branches of medication, from obstetrics to cardiology, from psychiatry to orthopedics.

This ebook offers an summary of our present figuring out of this significant ailment. It comprises the most recent info at the new pathogenetic mechanisms concerned in addition to medical manifestations in either ''the thrombotic” and ''non-thrombotic” manifestations of this crucial affliction.

* complete overview of this significant disease
* comprises details on cures to be had

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Extra resources for Antiphospholipid Syndrome in Systemic Autoimmune Diseases

Sample text

Investigators of the European Forum on 24 T. Mehrani, M. , 2002). , 2002). , 2002). Generally, LA assays are more specific and less sensitive than aCL for APS, with LA positivity found in about 20% of patients with APS (Bertolaccini and Khamashta, 2006). , 2006). , 2004b). , 2004b). , 2004b). , 2004b). , 2005). , 2006). , 2006). , 1999). , 1997). , 1997). , 1999). , 2006). , 2006). , 1991). In conclusion, progress in the standardization of measurement of aPL has been made. However, there is clearly a need for development of more specific laboratory assays to capture those patients at particular risk of thrombosis or pregnancy morbidity (Bertolaccini and Khamashta, 2006).

J. Haematol. 108, 126–131. P. 1996. The prevalence and clinical associations of anticardiolipin antibodies in a large inception cohort of patients with connective tissue diseases. Am. J. Med. 101, 576–583. A. 2006. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J. Thromb. Haemost. 4, 295–306. , et al. 1997. Variability of anticardiolipin isotype distribution in 3 geographic populations of patients with systemic lupus erythematosus.

Blood 101, 1827–1832. , et al. 1992. Anticardiolipin antibodies and the risk for ischemic stroke and venous thrombosis. Ann. Intern. Med. 117, 997–1002. , Serrano, A. 2004. Antiphospholipid syndrome and asymptomatic carriers of antiphospholipid antibody: prospective analysis of 404 individuals. J. Rheumatol. 31, 1560–1567. , Wang, P. 1999. Evidence that anticardiolipin antibodies are independent risk factors for atherosclerotic vascular disease. Am. J. Cardiol. 83, 1490–1494. , Alarcon-Segovia, D.

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Antiphospholipid Syndrome in Systemic Autoimmune Diseases by Ricard Cervera, Gerard Espinosa, Munther Khamashta MD FRCP PhD


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