Download PDF by Matthias Dehmer, Frank Emmert-Streib, Armin Graber, Armindo: Applied Statistics for Network Biology: Methods in Systems
By Matthias Dehmer, Frank Emmert-Streib, Armin Graber, Armindo Salvador
This publication introduces a couple of leading edge statistical tools which are used for the research of genomic, proteomic and metabolomic facts units. particularly within the box of platforms biology, researchers try to investigate as much information as attainable in a given organic method (such as a cellphone or an organ). the correct statistical overview of those huge scale information is important for the right kind interpretation and assorted experimental ways require assorted methods for the statistical research of those info. This publication is written by way of biostatisticians and mathematicians yet geared toward experimental researcher in addition to computational biologists who frequently lack a suitable heritage in statistical research.
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Additional resources for Applied Statistics for Network Biology: Methods in Systems Biology
When E. coli cells are exposed to various concentrations of mitomycin C (MMC), the application of MMC causes DNA damage that leads to the activation of protein RecA. Activated RecA cleaves the l CI repressor protein, resulting in the increase of the expression of gene lacI. Changes in gene expression levels will create an environment for cells to transfer from one steady state with high lcI expression level to the other steady state with high lacI expression level. In the absence of MMC, all cells exhibited little or no Green Fluorescent Protein (GFP) expression (low LacR expression).
3 4 Ø Àa! cIts; cIts Àa! 3 Comparison of simulation results with experimental observations for the genetic toggle switch interfaced with the SOS signaling pathway. Numbers of cells with different LacR molecular numbers are based on 1000 simulations and experimental observations in fluorescence signaling are derived from Figure 3(b) in  using the top and right labels. (a) s ¼ 1:3: no cell has high LacR expression level and no MMC was applied in experiments. 9% of cells have high LacR expression levels and 1 ng/ml MMC was applied.
4 shows that the right operator region OR consists of three binding sites. The dimeric forms of repressor and cro bind to these binding sites to regulate the transcription of genes cI and cro [78, 79, 83]. Biochemical reactions in this system are classiﬁed into fast reactions and slow reactions. Fast reactions include two monomer–dimer reactions and binding reactions of ligands to the promoter sites, and they are assumed to be in an equilibrium state. Slow reactions represent transcription and degradation.
Applied Statistics for Network Biology: Methods in Systems Biology by Matthias Dehmer, Frank Emmert-Streib, Armin Graber, Armindo Salvador